Cisplatin-induced aki

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August undefined, 2024

Web3.1 Cisplatin-induced AKI (nephrotoxin) Researchers first learned that platinum compounds could prevent cell division in 1960s. The U.S. Food and Drug Administration … WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). Unfortunately, there are no therapeutic ...

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

WebFeb 24, 2024 · Through experiments with a cisplatin-induced AKI model in vitro and in vivo, Baliga et al. suggested that cisplatin treatment led to increased expression of non … WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … can a real estate agent sell a floating house

Significance of downregulation of renal organic cation transporter ...

WebOct 15, 2024 · Acute kidney injury (AKI) is a sudden reduction in kidney activity and has a high mortality rate. Salvianolic acid C (SAC), one of the main polyphenolic components of Salvia miltiorrhiza, displays significant pharmacologically active effects.An animal model of cisplatin-induced kidney injury was used to study the potential of SAC to improve AKI. Websuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH ratio signiﬁcantly decreased with cisplatin treatment suggesting that cisplatin induced oxidative stress response in the kidney. GSH/oxidized GSH ratio is known to be an WebIn a preclinical mouse model, intraperitoneal perfusion with cisplatin induced AKI, whereas hyperthermia alone, or in combination with cisplatin, did not induce or enhance renal injury. Amifostine failed to confer nephroprotective effects in a miniaturized HIPEC model. Conclusions: AKI is a frequent complication after HIPEC. The risk of renal ... can a real estate agent buy their own listing

Pathophysiology of Cisplatin-Induced Acute Kidney Injury - Hindawi

Mechanisms of Cisplatin-Induced Acute Kidney Injury ... - MDPI

WebIn the present study we investigated the effects of MSC-derived MVs in SCID mice survival in lethal cisplatin-induced AKI. Moreover, we evaluated in vitro the effect of MVs on cisplatin-induced apoptosis of human renal tubular epithelial cells and the molecular mechanisms involved. Two different regimens of MV injection were used. WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … can a real estate agent give credit to buyerWebAug 6, 2014 · It may be concluded that, in cisplatin-induced AKI, activation of TLR4 on renal parenchymal cells may activate p38-MAPK pathways leading to nephrotoxicity . In summary TNF-alpha and IL-33 are proinflammatory cytokines that mediate cisplatin-induced AKI while IL-10 is an anti-inflammatory cytokine that protects against cisplatin … can a real estate agent show me any home

"WebPurpose: Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20-40% of exposed patients, despite any implemented precaution to avoid … " - Cisplatin-induced aki

Cisplatin-induced aki

Drug-Induced Acute Kidney Injury : Clinical Journal of the …

WebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to … WebJan 3, 2024 · Cisplatin-induced acute kidney injury (CI-AKI) is a significant co-morbidity of chemotherapeutic regimens. While this condition is associated with substantially lower …

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WebMar 29, 2024 · The purpose of this article is to consolidate cisplatin-induced acute kidney injury literature and present it in one collective paper. It explores each individual … WebCisplatin-induced AKI typically occurs 5–7 days after therapy, whereas dialysis-requiring AKI is uncommon in the absence of concomitant nephrotoxic exposures. AKI typically …

WebAug 6, 2014 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. There is … WebDec 16, 2024 · Introduction. Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. (1–3) Cisplatin-induced nephrotoxicity is …

WebApr 6, 2015 · Acute kidney injury (AKI) is a common clinical condition caused by loss of kidney function. Lack of therapeutic options has contributed to high mortality rates in AKI patients. Drug-induced AKI, as observed during cisplatin-based anticancer therapy, is responsible for about 20% of renal failure cases. WebDec 21, 2024 · The clinical use of cisplatin has been hampered by its dose-dependent side effects, e.g., nephrotoxicity, and the precise mechanism(s) related to such a cisplatin-induced acute kidney injury (AKI) remain elusive, despite many investigations that were devoted to this subject matter over a period of decades.

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … fish finder singaporeWebApr 25, 2014 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. There is … fish finder sitexWebsuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH … can a real estate agent use the title brokerWebMethods To investigate whether kidney-targeted delivery of renalase might prevent cisplatin-induced CKD in a mouse model, we achieved specific delivery of a renalase agonist peptide (RP81) to the renal proximal tubule by encapsulating the peptide in mesoscale nanoparticles (MNPs). We used genetic deletion of renalase, single-cell RNA … can a real estate agent pay a finder feeWebNational Center for Biotechnology Information fish finders live scopeWebMar 27, 2024 · Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to … fishfinder side scanWebFeb 24, 2024 · Through experiments with a cisplatin-induced AKI model in vitro and in vivo, Baliga et al. suggested that cisplatin treatment led to increased expression of non transferrin-bound iron . Additionally, deferoxamine (a chelating agent for removing excess iron) treatment significantly improved the functional and histological deterioration in ... fishfinders near me